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Title 

Four new neolignans isolated from Eleutherococcus senticosus and their protein tyrosine phosphatase 1B inhibitory activity (PTP1B)

Authors 

L ZhangB B LiH Z LiX MengX LinY Y JiangJong Seog AhnL Cui

Publisher 

Elsevier

Issue Date 

2017

Citation 

Fitoterapia

Keywords 

Eleutherococcus senticosusNeo-lignansObesityPTP1B

Abstract 

Four new compounds, erythro-7′E-4-hydroxy-3,3′-dimethoxy-8,5′-oxyneoligna-7′-ene-7,9-diol-9′-al (1), (7S,8S)-4-hydroxy-3,1′,3′-trimethoxy-4′,7-epoxy-8,5′-neolign-9-ol (5), (7S,8S,7′E)-5-hydroxy-3,3′-dimethoxy-4′,7-epoxy-8,5′-neolign-7′-ene-9,9′-diol (6) and (7S,8S,7′E)-5-hydroxy-3,3′,9′-trimethoxy-4′-7-epoxy-8,5′-neolign-7′-ene-9-ol (7). Along with four known compounds (2?4, 8) were isolated from the EtOAc-soluble extract of Eleutherococcus senticosus. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the compounds were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, compounds 1?4 and 6?8 were found to exhibit selective inhibitory activity on PTP1B with IC50 values ranging from 17.2 ± 1.6 to 32.7 ± 1.2 μM

ISSN 

0367-326X

Link 

http://dx.doi.org/10.1016/j.fitote.2017.06.025

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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