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Title 

Roles of gangliosides in the differentiation of mouse pluripotent stem cells to neural stem cells and neural cells

Authors 

Jae Sung RyuK KoJi-Su KimSun-Uk KimKyu Tae Chang

Publisher 

Spandidos Publications

Issue Date 

2017

Citation 

Molecular Medicine Reports

Keywords 

DifferentiationGangliosidesMarkerMouse neural cellsMouse neural stem cellsMouse pluripotent stem cells

Abstract 

Glycosphingolipids are important components of the outer layer of the plasma membrane in the majority of eukaryotic cells. Specifically, gangliosides are sialic acid-containing glycosphingolipids that participate in cell-cell recognition, adhesion, proliferation, differentiation and signal transduction, and are integral components of cell surface microdomains and lipid rafts. Stem cells are defined functionally as cells that have the capacity to self-renewal and differentiate to generate various cell types. Due to different synthesis patterns and locations of gangliosides, they have been used as molecular markers of stem cells. The current review describes the presence of gangliosides in various types of mouse stem cells, including pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells) and neural stem cells, and the functional roles of gangliosides in various processes, including cell proliferation and neural differentiation. Thus, this review will aid the understanding of gangliosides patterns and functions in mouse stem cells, and outline markers for the identification of stem cells.

ISSN 

1791-2997

Link 

http://dx.doi.org/10.3892/mmr.2017.6719

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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