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Title 

HX-1171, a novel Nrf2 activator, induces NQO1 and HMOX1 expression

Authors 

Jimin KimS H ShinYeong Eun KoT MikiH M BaeJ K KangJae Wha Kim

Publisher 

Wiley-Blackwell

Issue Date 

2017

Citation 

Journal of Cellular Biochemistry

Keywords 

ANTIOXIDANTHX-1171Nrf2OXIDATIVE STRESS

Abstract 

HX-1171 (1-O-hexyl-2,3,5-trimethylhydroquinone) is a novel synthesized vitamin E derivative, which reportedly has positive effects on various diseases and conditions, such as liver fibrosis, hepatic cirrhosis, and cancer. In this study, we analyzed the transcriptional activity induced by HX-1171. Results from reverse transcription polymerase chain reaction and promoter assays reveal that HX-1171 increased the expression of NQO1 and HMOX1, encoding antioxidant-related enzymes, in A549 human lung epithelial cells. The activity of nuclear factor-E2-related factor (Nrf2), a key transcriptional factor for antioxidative enzymes, was examined in HX-1171-treated cells. Confocal microscopy and Western blotting showed that HX-1171 effectively induced the nuclear translocation and transcriptional activity of Nrf2. We conclude that HX-1171, a novel Nrf2 activator, may be a promising therapeutic agent for oxidative stress-induced diseases. J. Cell. Biochem. 118: 3372?3380, 2017.

ISSN 

0730-2312

Link 

http://dx.doi.org/10.1002/jcb.25993

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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