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Title 

Gain switching for a detection system to accommodate a newly developed MALDI-based quantification method

Authors 

S H AhnT HyeonM S KimJeong Hee Moon

Publisher 

Elsevier

Issue Date 

2017

Citation 

Journal of American Society for Mass Spectrometry

Keywords 

Detector gain switchingMALDI quantificationMALDI-TOF instrument

Abstract 

In matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF), matrix-derived ions are routinely deflected away to avoid problems with ion detection. This, however, limits the use of a quantification method that utilizes the analyte-to-matrix ion abundance ratio. In this work, we will show that it is possible to measure this ratio by a minor instrumental modification of a simple form of MALDI-TOF. This involves detector gain switching. [Figure not available: see fulltext.].

ISSN 

1044-0305

Link 

http://dx.doi.org/10.1007/s13361-017-1711-2

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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