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Title 

Conifer diterpene resin acids disrupt juvenile hormone-mediated endocrine regulation in the Indian meal moth Plodia interpunctella

Authors 

Hyun Woo OhChan Seok YunJun Hyoung JeonJi Ae KimDoo-Sang ParkHyung Won RyuSei-Ryang OhH H SongY ShinC S JungSang Woon Shin

Publisher 

Springer Verlag (Germany)

Issue Date 

2017

Citation 

Journal of Chemical Ecology

Keywords 

Diterpene resin acidHerbivoreInsect developmentJuvenile hormoneJuvenile hormone antagonistPlant defenseTerpenes

Abstract 

Diterpene resin acids (DRAs) are important components of oleoresin and greatly contribute to the defense strategies of conifers against herbivorous insects. In the present study, we determined that DRAs function as insect juvenile hormone (JH) antagonists that interfere with the juvenile hormone-mediated binding of the JH receptor Methoprene-tolerant (Met) and steroid receptor coactivator (SRC). Using a yeast two-hybrid system transformed with Met and SRC from the Indian meal moth Plodia interpunctella, we tested the interfering activity of 3704 plant extracts against JH III-mediated Met-SRC binding. Plant extracts from conifers, especially members of the Pinaceae, exhibited strong interfering activity, and four active interfering DRAs (7α-dehydroabietic acid, 7-oxodehydroabietic acid, dehydroabietic acid, and sandaracopimaric acid) were isolated from roots of the Japanese pine Pinus densiflora. The four isolated DRAs, along with abietic acid, disrupted the juvenile hormone-mediated binding of P. interpunctella Met and SRC, although only 7-oxodehydroabietic acid disrupted larval development. These results demonstrate that DRAs may play a defensive role against herbivorous insects via insect endocrine-disrupting activity.

ISSN 

0098-0331

Link 

http://dx.doi.org/10.1007/s10886-017-0861-9

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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