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Title 

The fungal metabolite brefeldin A inhibits Dvl2-Plk1-dependent primary cilium disassembly

 

곰팡이 대사산물인 Brefeldin A의 Dvl2-Plk1 의존적 일차섬모 분해억제효과

Authors 

Uijeong LeeSun Ok KimJeong Ah HwangJae-Hyuk JangSangkeun SonIn Ja RyooJong Seog AhnBo Yeon KimKyung Ho Lee

Publisher 

Springer Verlag (Germany)

Issue Date 

2017

Citation 

Molecules and Cells

Keywords 

Brefeldin ADvl2InhibitorPlk1Primary cilium disassembly

Abstract 

The primary cilium is a non-motile microtubule-based organelle that protrudes from the surface of most human cells and works as a cellular antenna to accept extracellular signals. Primary cilia assemble from the basal body during the resting stage (G0 phase) and simultaneously disassemble with cell cycle re-entry. Defective control of assembly or disassembly causes diverse human diseases including ciliopathy and cancer. To identify the effective compounds for studying primary cilium disassembly, we have screened 297 natural compounds and identified 18 and 17 primary cilium assembly and disassembly inhibitors, respectively. Among them, the application of KY-0120, identified as Brefeldin A, disturbed Dvl2- Plk1-mediated cilium disassembly via repression of the interaction of CK1ε-Dvl2 and the expression of Plk1 mRNA. Therefore, our study may suggest useful compounds for studying the cellular mechanism of primary cilium disassembly to prevent ciliopathy and cancer

ISSN 

1016-8478

Link 

http://dx.doi.org/10.14348/molcells.2017.0032

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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