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Title 

miR-150-mediated Foxo1 regulation programs CD8+ T cell differentiation

Authors 

Y H BanSe-Chan OhSang-Hwan SeoSeok-Min KimIn Pyo ChoiP D GreenbergJ ChangTae-Don KimS J Ha

Publisher 

Elsevier

Issue Date 

2017

Citation 

Cell Reports

Keywords 

acuteCD8differentiationFoxo1infectionLCMVmemorymiR-150primary immune responserecall

Abstract 

MicroRNA (miR)-150 is a developmental regulator of several immune-cell types, but its role in CD8+ T cells is largely unexplored. Here, we show that miR-150 regulates the generation of memory CD8+ T cells. After acute virus infection, miR-150 knockout (KO) mice exhibited an accelerated differentiation of CD8+ T cells into memory cells and improved production of effector cytokines. Additionally, miR-150 KO CD8+ T cells displayed an enhanced recall response and improved protection against infections with another virus and bacteria. We found that forkhead box O1 (Foxo1) and T cell-specific transcription factor 1 (TCF1) are upregulated during the early activation phase in miR-150 KO CD8+ T cells and that miR-150 directly targets and suppresses Foxo1. These results suggest that miR-150-mediated suppression of Foxo1 regulates the balance between effector and memory cell differentiation, which might aid in the development of improved vaccines and T cell therapeutics

ISSN 

2211-1247

Link 

http://dx.doi.org/10.1016/j.celrep.2017.08.065

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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