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Title 

Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities

Authors 

Jun-Pil JangH J JungJ M HanN JungY KimH J KwonSung-Kyun KoNak Kyun SoungJae-Hyuk JangJong Seog Ahn

Publisher 

Public Library of Science

Issue Date 

2017

Citation 

Plos One

Abstract 

In the course of searching for angiogenesis inhibitors from microorganisms, two cyclic peptides, PF1171A (1) and PF1171C (2) were isolated from the soil fungus Penicillium sp. FN070315. In the present study, we investigated the antiangiogenic efficacy and associated mechanisms of 1 and 2 in vitro using human umbilical vein endothelial cells (HUVECs). Compounds 1 and 2 inhibited the proliferation of HUVECs at concentrations not exhibiting cytotoxicity. Moreover, 1 and 2 significantly suppressed vascular endothelial growth factor (VEGF)-induced migration, invasion, proliferation and tube formation of HUVECs as well as neovascularization of the chorioallantoic membrane in developing chick embryos. We also identified an association between the antiangiogenic activity of 1 and 2 and the downregulation of both the phosphorylation of VEGF receptor 2 and the expression of hypoxia inducible factor-1α at the protein level. Taken together, these results further suggest that compounds 1 and 2 will be promising angiogenesis inhibitors.

ISSN 

1932-6203

Link 

http://dx.doi.org/10.1371/journal.pone.0184339

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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