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Title 

Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice

Authors 

S SukG T KwonE LeeW J JangH YangJ H KimN R ThimmegowdaM Y ChungJ Y KwonS YangJ K KimJ H Yoon ParkK W Lee

Publisher 

Wiley-Blackwell

Issue Date 

2017

Citation 

Molecular Nutrition & Food Research

Keywords 

AdipocyteAdipose tissue inflammationAMP-activated protein kinaseGingerenone AObesity

Abstract 

Scope: Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti-obesity effect of gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI). Methods and results: Oil red O staining showed that GA had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components tested at a single concentration (40 μM). Consistent with in vitro data, GA attenuates DIO by reducing fat mass in mice. This was accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in vitro and in vivo. Additionally, GA suppressed ATI by inhibiting macrophage recruitment and downregulating pro-inflammatory cytokines. Conclusion: These results suggest that GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation.

ISSN 

1613-4125

Link 

http://dx.doi.org/10.1002/mnfr.201700139

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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