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Title 

Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1

Authors 

Hyun Ah ParkJae Won LeeOk-Kyoung KwonGilhye LeeYurim LimJung Hee KimJin Hyub PaikSangho ChoiI ParyantoP YuniatoDoo-Young KimHyung Won RyuSei-Ryang OhS J LeeKyung Seop Ahn

Publisher 

Spandidos Publications

Issue Date 

2017

Citation 

International Journal of Molecular Medicine

Keywords 

Airway inflammationChronic obstructive pulmonary diseaseHeme oxygenase-1NeutrophilsPhysalis peruviana L.

Abstract 

Physalis peruviana L. (PP) is a medicinal herb that has been confirmed to have several biological activities, including anticancer, antioxidant and anti-inflammatory properties. The aim of the present study was to evaluate the protective effect of PP on cigarette smoke (CS)- and lipopolysaccharide (LPS)-induced pulmonary inflammation. Treatment with PP significantly reduced the influx of inflammatory cells in the bronchoalveolar lavage fluid (BALF) and lung of mice with CS- and LPS-induced pulmonary inflammation. PP also decreased the levels of reactive oxygen species (ROS) and pro-inflammatory cytokines, such as tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) in the BALF. PP effectively attenuated the expression of monocyte chemoattractant protein-1 (MCP-1) and the activation of extracellular signal-regulated kinase (ERK) in the lung. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) activation and heme oxygenase-1 (HO-1) expression were increased by PP treatment. In an in vitro experiment, PP reduced the mRNA expression of TNF-a and MCP-1, and the activation of ERK in CS extract-stimulated A549 epithelial cells. Furthermore, PP increased the activation of Nrf2 and the expression of HO-1 in A549 cells. These findings suggest that PP has a therapeutic potential for the treatment of pulmonary inflammatory diseases, such as chronic obstructive pulmonary disease.

ISSN 

1107-3756

Link 

http://dx.doi.org/10.3892/ijmm.2017.3139

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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