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Title 

Anti-inflammatory activity of eudesmane-type sesquiterpenoids from Salvia plebeia

Authors 

Hyun-Jae JangSoyoung LeeSeung Jae LeeHyung Jin LimKyungsook JungY H KimSeung Woong LeeMun Chual Rho

Publisher 

American Chemical Society

Issue Date 

2017

Citation 

Journal of Natural Products

Abstract 

Nine new sesquiterpenoid lactones and 11 known analogues were isolated from the aerial parts of Salvia plebeia R.Br. Their structures were elucidated via HRESIMS and NMR data, and their absolute configurations were defined via electronic circular dichroism data, X-ray crystallographic analysis, and the modified Mosher's ester method. Compounds 1-20 were investigated for their ability to inhibit LPS-stimulated nitric oxide production in murine macrophage cells. Of the isolates, epi-eudebeiolide C (20) showed the highest inhibitory effect (IC50 of 17.9 μM). mRNA and protein expression of inducible nitric oxide synthase (iNOS), but not that of cyclooxygenase-2 (COX-2), was dose-dependently decreased by 20 in LPS-activated RAW 264.7 cells. Based on a mechanistic study involving the nuclear factor-κB (NF-κB) signaling pathway, the anti-inflammatory effect of 20 was attributed to NF-κB activation blockade via inhibition of NF-κB (IκB) phosphorylation. Therefore, 20 might be a potential candidate for relieving inflammatory diseases.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/acs.jnatprod.7b00326

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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