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Title 

Peroxiredoxin I participates in the protection of reactive oxygen species-mediated cellular senescence

 

세포 노화에서 활성산소에 의한 퍼록시레독신 I 역할

Authors 

Young-Ho ParkH S KimJong-Hee LeeSeon A ChoiJ M KimG T OhS W KangSun-Uk KimDae Yeul Yu

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2017

Citation 

BMB Reports

Keywords 

Antioxidant enzymeCellular senescenceOxidative stressp16INK4aPeroxiredoxin

Abstract 

Peroxiredoxin I (Prx I) plays an important role as a reactive oxygen species (ROS) scavenger in protecting and maintaining cellular homeostasis; however, the underlying mechanisms are not well understood. Here, we identified a critical role of Prx I in protecting cells against ROS-mediated cellular senescence by suppression of p16INK4a expression. Compared to wild-type mouse embryonic fibroblasts (WT-MEFs), Prx I-/- MEFs exhibited senescence-associated phenotypes. Moreover, the aged Prx I-/- mice showed an increased number of cells with senescence associated-β-galactosidase (SA-β-gal) activity in a variety of tissues. Increased ROS levels and SA-β-gal activity, and reduction of chemical antioxidant in Prx I-/- MEF further supported an essential role of Prx I peroxidase activity in cellular senescence that is mediated by oxidative stress. The up-regulation of p16INK4a expression in Prx I-/- and suppression by overexpression of Prx I indicate that Prx I possibly modulate cellular senescence through ROS/p16INK4a pathway

ISSN 

1225-8687

Link 

http://dx.doi.org/10.5483/BMBRep.2017.50.http://dx.doi.org/10.121

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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