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Title 

Antioxidant and anticancer potential of bioactive compounds following UV-C light-induced plant cambium meristematic cell cultures

Authors 

So Hyun MoonB MistryD H KimM Pandurangan

Publisher 

Elsevier

Issue Date 

2017

Citation 

Industrial Crops and Products

Keywords 

Anticancer activityAntioxidant activityFlavonoidsPhenolicTerpenoid indole alkaloidsUltraviolet C

Abstract 

Catharanthus roseus (L.) G. Don is a well-known medicinal plant as a potent anticancer agent that produces rich of secondary metabolites, such as phytochemicals, terpenoid indole alkaloids (TIAs) including catharanthine, vinblastine, vincristine, vindoline. In the present study illustrates the changes in phenolic contents, TIA contents and their biosynthesis pathway with High Performance Liquid Chromatography (HPLC) and quantitative reverse-transcription polymerase chain reaction qRT-PCR, and investigation of antioxidant and anticancer potential with their correlation by different Ultraviolet-C (UV-C) treated the condition in cambium meristematic cells (CMCs) from C. roseus. The UV-C was found to process high antioxidant capacity and anticancer potential. Moreover, the UV-C treatment enhanced accumulation of bioactive compounds such as total flavonoids, total phenolic, and TIAs, and also found a correlation with upregulation of TIA biosynthesis pathway genes. These results indicate that the UV-C treated C. roseus CMCs is a potential candidate to be used as natural antioxidant, anticancer agent and treatments of UV-C can be used as an efficient method to enhance bioactive compounds

ISSN 

0926-6690

Link 

http://dx.doi.org/10.1016/j.indcrop.2017.09.024

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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