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Title 

Dorsal and ventral hippocampus differentiate in functional pathways and differentially associate with neurological disease-related genes during postnatal development

Authors 

A R LeeJong Hwan KimE ChoMirang KimM Park

Publisher 

Frontiers Media

Issue Date 

2017

Citation 

Frontiers in Molecular Neuroscience

Keywords 

Dorsal hippocampusNeurological diseasesPostnatal developmentRNA-seqTranscriptomeVentral hippocampus

Abstract 

The dorsal and ventral regions of the hippocampus are important in cognitive and emotional processing, respectively. Various approaches have revealed the differential molecular and structural characteristics, and functional roles of the hippocampus. Recent RNA sequencing (RNA-seq) technology has enriched our understanding of the hippocampus by elucidating more detailed information on gene expression patterns. However, no RNA-seq?based study on gene profiles in the developing hippocampus has been reported. Using RNA-seq?based bioinformatic analysis in conjunction with quantitative real-time polymerase chain reaction analysis and a comparison of in situhybridization data obtained from the Allen Brain Atlas, we provide a thorough analysis of differentially expressed genes in the dorsal and ventral hippocampus at specific developmental ages representing the postnatally maturing hippocampus. Genes associated with particular functional pathways and marker genes for particular neurological diseases were found to be distinctively segregated within either the dorsal or ventral hippocampus at specific or at all developmental ages examined. We also report novel molecular markers enriched in the dorsal or ventral hippocampus. Taken together, this study provides insights into the molecular mechanisms underlying physiological functions linked to the dorsal or ventral hippocampus. The information provided in the study also contributes to a better understanding of brain functions and serves as a resource for future studies on the pathophysiology of dorsal and ventral hippocampal functions

ISSN 

1662-5099

Link 

http://dx.doi.org/10.3389/fnmol.2017.00331

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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