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Title 

Experimental infection of clade 1.1.2 (H5N1), clade 2.3.2.1c (H5N1) and clade 2.3.4.4 (H5N6) highly pathogenic avian influenza viruses in dogs

Authors 

K S LyooW NaL V PhanSun Woo YoonM YeomD SongDae Gwin Jeong

Publisher 

Wiley

Issue Date 

2017

Citation 

Transboundary and Emerging Diseases

Keywords 

dogH5N1H5N6highly pathogenic avian influenzareassortment

Abstract 

Since the emergence of highly pathogenic avian influenza (HPAI) H5N1 in Asia, the haemagglutinin (HA) gene of this virus lineage has continued to evolve in avian populations, and H5N1 lineage viruses now circulate concurrently worldwide. Dogs may act as an intermediate host, increasing the potential for zoonotic transmission of influenza viruses. Virus transmission and pathologic changes in HPAI clade 1.1.2 (H5N1)-, 2.3.2.1c (H5N1)- and 2.3.4.4 (H5N6)-infected dogs were investigated. Mild respiratory signs and antibody response were shown in dogs intranasally infected with the viruses. Lung histopathology showed lesions that were associated with moderate interstitial pneumonia in the infected dogs. In this study, HPAI H5N6 virus replication in dogs was demonstrated for the first time. Dogs have been suspected as a “mixing vessel” for reassortments between avian and human influenza viruses to occur. The replication of these three subtypes of the H5 lineage of HPAI viruses in dogs suggests that dogs could serve as intermediate hosts for avian?human influenza virus reassortment if they are also co-infected with human influenza viruses.

ISSN 

1865-1674

Link 

http://dx.doi.org/10.1111/tbed.12731

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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