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Title 

Differential effects of EGFL6 on tumor versus wound angiogenesis

Authors 

Kyung Hee NohL S MangalaH D HanN ZhangS PradeepS Y WuS MaE MoraR RupaimooleD JiangY WenM M K ShahzadY LyonsM ChoW HuA S NagarajaM HaemmerleC S L MakX ChenK M GharpureH DengW XiongC V XiongJ LiuN JenningsM J BirrerR R BouchardG Lopez-BeresteinR L ColemanZ AnA K Sood

Publisher 

Elsevier

Issue Date 

2017

Citation 

Cell Reports

Keywords 

chitosan nanoparticlesovarian cancertumor endothelial cellstumor vasculaturewound healing

Abstract 

Angiogenesis inhibitors are important for cancer therapy, but clinically approved anti-angiogenic agents have shown only modest efficacy and can compromise wound healing. This necessitates the development of novel anti-angiogenesis therapies. Here, we show significantly increased EGFL6 expression in tumor versus wound or normal endothelial cells. Using a series of in vitro and in vivo studies with orthotopic and genetically engineered mouse models, we demonstrate the mechanisms by which EGFL6 stimulates tumor angiogenesis. In contrast to its antagonistic effects on tumor angiogenesis, EGFL6 blockage did not affect normal wound healing. These findings have significant implications for development of anti-angiogenesis therapies. Noh et al. identify EGFL6 as an angiogenic target that is selectively present in tumor endothelial cells in a hypoxic tumor microenvironment. EGFL6 blockade exerts robust anti-angiogenic and anti-tumor effects without affecting wound healing. These findings suggest an important approach for effectively targeting tumor angiogenesis

ISSN 

2211-1247

Link 

http://dx.doi.org/10.1016/j.celrep.2017.11.020

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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