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Title 

Metabolic signaling to epigenetic alterations in cancer

Authors 

Jung Ae KimYoung Il Yeom

Publisher 

Korean Society of Applied Pharmacology

Issue Date 

2018

Citation 

Biomolecules & Therapeutics

Keywords 

AcetylationCancerEpigeneticsMetabolismMetastasisMethylation

Abstract 

Cancer cells reprogram cellular metabolism to support the malignant features of tumors, such as rapid growth and proliferation. The cancer promoting effects of metabolic reprogramming are found in many aspects: generating additional energy, providing more anabolic molecules for biosynthesis, and rebalancing cellular redox states in cancer cells. Metabolic pathways are considered the pipelines to supply metabolic cofactors of epigenetic modifiers. In this regard, cancer metabolism, whereby cellular metabolite levels are greatly altered compared to normal levels, is closely associated with cancer epigenetics, which is implicated in many stages of tumorigenesis. In this review, we provide an overview of cancer metabolism and its involvement in epigenetic modifications and suggest that the metabolic adaptation leading to epigenetic changes in cancer cells is an important non-genetic factor for tumor progression, which cooperates with genetic causes. Understanding the interaction of metabolic reprogramming with epigenetics in cancers may help to develop novel or highly improved therapeutic strategies that target cancer metabolism

ISSN 

1976-9148

Link 

http://dx.doi.org/10.4062/biomolther.2017.185

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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