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Title 

Suppression of RANKL-induced osteoclastogenesis by the metabolites from the marine fungus Aspergillus flocculosus isolated from a sponge Stylissa sp.

Authors 

H J ShinB K ChoiP T H TrinhH S LeeJong Soon KangT T T VanJ S LeeY J LeeJ Lee

Publisher 

MDPI

Issue Date 

2018

Citation 

Marine Drugs

Keywords 

Aspergillus flocculosusTRAP assaymactanamidemarine fungusosteoclastogenesis

Abstract 

A new α-pyrone merosesquiterpenoid possessing an angular tetracyclic carbon skeleton, ochraceopone F (1), and four known secondary metabolites, aspertetranone D (2), cycloechinulin (3), wasabidienone E (4), and mactanamide (5), were isolated from the marine fungus Aspergillus flocculosus derived from a sponge Stylissa sp. collected in Vietnam. The structures of Compounds 1?5 were elucidated by analysis of 1D and 2D NMR spectra and MS data. All the isolated compounds were evaluated for anti-proliferation activity and their suppression effects on receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation using tartate-resisant acid phosphatase (TRAP). Compounds 1?5 had no anti-proliferative effect on human cancer cell lines up to 30 ?g/mL. Among these compounds, aspertetranone D (2) and wasabidienone E (4) exhibited weak osteoclast differentiation inhibitory activity at 10 ?g/mL. However, mactanamide (5) showed a potent suppression effect of osteoclast differentiation without any evidence of cytotoxicity.

ISSN 

1660-3397

Link 

http://dx.doi.org/10.3390/md16010014

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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