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Title 

Selective oncolytic effect in Epstein-Barr virus (EBV)-associated gastric carcinoma through efficient lytic induction by euphorbia extracts

 

대극의 EBV 활성화를 통한 oncolytic 효과

Authors 

Dong-Eun KimSunhee JungHyung Won RyuMiri ChoiMingu KangHyunju KangHeung Joo YukHyejeong JeongJiyeon BaekJ H SongJanghwan KimH KangS B HanSei-Ryang OhSungchan Cho

Publisher 

Elsevier

Issue Date 

2018

Citation 

Journal of Functional Foods

Keywords 

EBV-associated gastric carcinomaEpstein-Barr virusEuphorbiaLytic inductionMedicinal plant extracts

Abstract 

Lytic induction of latent Epstein-Barr virus (EBV) has been considered as a therapeutic approach for efficient treatment of EBV-associated malignancies. Here, we established a robust assay system quantitatively measuring EBV lytic induction and identified three Euphorbia extracts as strong inducers from a screen of Korean medicinal plant extracts library. Expression of lytic genes were efficiently induced by each Euphorbia extract in SNU-719 (EBV-positive gastric carcinoma cells). Euphorbia pekinensis, out of three extracts, exhibited the most potent lytic-inducing activity. Importantly, treatment with E. pekinensis extract led to an obvious cytotoxic effect on SNU-719 cells, but little on MKN-74 cells (EBV-negative gastric carcinoma cells), indicating the selective oncolytic effect on EBV-positive gastric carcinoma. We further revealed that lytic-inducing activity of E. pekinensis was mediated by PKC/MEK signal. Moreover, we defined two structural analogs of PMA with strong lytic-inducing activity, suggesting their therapeutic applicability for the treatment of EBV-associated gastric carcinoma

ISSN 

1756-4646

Link 

http://dx.doi.org/10.1016/j.jff.2018.01.004

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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