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Title 

VBP1 represses cancer metastasis by enhancing HIF-1α degradation induced by pVHL

Authors 

J A KimD K ChoiJ S MinI KangJ C KimSemi KimJ K Ahn

Publisher 

Wiley-Blackwell

Issue Date 

2018

Citation 

FEBS Journal

Keywords 

EMTpVHLHIF-1αVBP1metastasis

Abstract 

von Hippel-Lindau-binding protein 1 (VBP1) physically interacts with pVHL, an E3-ubiquitin ligase, which degrades HIF-1α in an oxygen-dependent manner. HIF-1 is a key regulator of adaptive responses to a lack of oxygen that controls glucose metabolism, angiogenesis, proliferation, invasion, and metastasis. However, the role of VBP1 in pVHL-mediated degradation of HIF-1α is not yet known. In this study, we show that VBP1 enhances the stability of pVHL and facilitates pVHL-mediated ubiquitination of HIF-1α. Furthermore, VBP1 suppresses HIF-1α-induced epithelial-mesenchymal transition in vitro and tumor metastasis in vivo. These findings suggest that VBP1 is a bona fide tumor suppressor protein associated with HIF-1α regulation.

ISSN 

1742-464X

Link 

http://dx.doi.org/10.1111/febs.14322

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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