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Title 

EHMT2 is a metastasis regulator in breast cancer

Authors 

Kwangho KimMi Young SonCho Rok JungDae Soo KimHyun Soo Cho

Publisher 

Elsevier

Issue Date 

2018

Citation 

Biochemical and Biophysical Research Communications

Keywords 

Breast cancerEHMT2InvasionMetastasisMigration

Abstract 

Various modes of epigenetic regulation of breast cancer proliferation and metastasis have been investigated, but epigenetic mechanisms involved in breast cancer metastasis remain elusive. Thus, in this study, EHMT2 (a histone methyltransferase) was determined to be significantly overexpressed in breast cancer tissues and in Oncomine data. In addition, knockdown of EHMT2 reduced cell migration/invasion and regulated the expression of EMT-related markers (E-cadherin, Claudin 1, and Vimentin). Furthermore, treatment with BIX-01294, a specific inhibitor of EHMT2, affected migration/invasion in MDA-MB-231 cells. Therefore, our findings demonstrate functions of EHMT2 in breast cancer metastasis and suggest that targeting EHMT2 may be an effective therapeutic strategy for preventing breast cancer metastasis

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2018.01.074

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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