상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Enhancement of L-threonine production through controlling sequential carbon-nitrogen ratios during fermentation

Authors 

Hyeok Won LeeHee Suk LeeChun Suk KimJin Gyeom LeeWon-Kyo KimEun Gyo LeeHong-Weon Lee

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2018

Citation 

Journal of Microbiology and Biotechnology

Keywords 

L-threoninefeeding ratio (Rc/n)feeding strategyresidual glucose concentrationscale-up

Abstract 

Controlling the residual glucose concentration is important for improving productivity in L-threonine fermentation. In this study, we developed a procedure to automatically control the feeding quantity of glucose solution as a function of ammonia-water consumption rate. The feeding ratio (RC/N) of glucose and ammonia water was predetermined via a stoichiometric approach, on the basis of glucose-ammonia water consumption rates. In a 5-L fermenter, 102 g/l L-threonine was obtained using our glucose-ammonia water combined feeding strategy, which was then successfully applied in a 500-L fermenter (89 g/l). Therefore, we conclude that an automatic combination feeding strategy is suitable for improving L-threonine production

ISSN 

1017-7825

Link 

http://dx.doi.org/10.4014/jmb.1708.08072

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)