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Title 

An efficient synthetic protocol for amide derivatives of Boc-2-aminoisobutyrate

Authors 

M JoS W WonD G LeeJ K JungSunhong KimY S Kwak

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2018

Citation 

Archives of Pharmacal Research

Keywords 

Methyl Boc-aminoisobutyrateSteric challengeTransmidationt-butylmagnesiumchloride

Abstract 

Abstract: Aminoisobutyric acid (AIB) is an important building block widely incorporated by medicinal chemists in molecular design. Owing to the steric challenge, elaborating AIB’s carboxylic acid using conventional amidation protocols is often problematic. We discovered that an amidation protocol utilizing methyl Boc-aminoisobutyrate and magnesium amidates of various reactivities produces the corresponding amide derivatives in good to excellent yields

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-018-1009-3

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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