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Title 

Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages

 

파시플로라 페티다의 항염 효과

Authors 

Ji Won ParkOk-Kyoung KwonHyung Won RyuJin Hyub PaikI ParyantoP YuniatoSangho ChoiSei-Ryang OhKyung Seop Ahn

Publisher 

Spandidos Publications

Issue Date 

2018

Citation 

International Journal of Molecular Medicine

Keywords 

InflammationLipopolysaccharideMAPKNuclear factor-κBPassiflora foetida L.

Abstract 

Passiflora foetida L. (Passifloraceae), a perennial climber in general, is used for treating many ailments in conventional medicine. In this study, the anti-inflammatory effect of methanolic extracts of P. foetida L. (PFME) and the involvement of nuclear factor-κB (NF-κB) signalling in the regulation of inflammation were investigated. PFME prevented the production of prostaglandin E2 (PGE2) and the expression of inducible cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced macrophage cells. Additionally, PFME reduced the release of pro-inflammatory cytokines. Moreover, in LPS-induced RAW264.7 cells, the phosphorylation of MAPKs (ERK1/2, p38 and JNK) was suppressed by PFME. Furthermore, PFME inhibited the NF-κB activation induced by LPS, which was associated with nuclear p65 levels with the abrogation of IκBα degradation and subsequent decreases. These results indicated that the PFME inhibited the LPS-induced inflammatory and oxidative responses. Therefore, we propose that the PFME may be therapeutic for treating inflammatory diseases.

ISSN 

1107-3756

Link 

http://dx.doi.org/10.3892/ijmm.2018.3559

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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