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Title 

Functional analysis of Methylomonas sp. DH-1 genome as a promising biocatalyst for bioconversion of methane to valuable chemicals

Authors 

A D NguyenI Y HwangO K LeeD H HurY C JeonS HadiyatiM S KimS H YoonHaeyoung JeongE Y Lee

Publisher 

MDPI

Issue Date 

2018

Citation 

Catalysts

Keywords 

Complete genome sequenceDH-1MethaneMethylomonas spSecondary metabolites

Abstract 

Methylomonas sp. DH-1, newly isolated from the activated sludge of a brewery plant, has been used as a promising biocatalytic platform for the conversion of methane to value-added chemicals. Methylomonas sp. DH-1 can efficiently convert methane and propane into methanol and acetone with a specific productivity of 4.31 and 0.14 mmol/g cell/h, the highest values ever reported, respectively. Here, we present the complete genome sequence of Methylomonas sp. DH-1 which consists of a 4.86 Mb chromosome and a 278 kb plasmid. The existence of a set of genes related to one-carbon metabolism and various secondary metabolite biosynthetic pathways including carotenoid pathways were identified. Interestingly, Methylomonas sp. DH-1 possesses not only the genes of the ribulose monophosphate cycle for type I methanotrophs but also the genes of the serine cycle for type II. Methylomonas sp. DH-1 accumulated 80 mM succinate from methane under aerobic conditions, because DH-1 has 2-oxoglutarate dehydrogenase activity and the ability to operate the full TCA cycle. Availability of the complete genome sequence of Methylomonas sp. DH-1 enables further investigations on the metabolic engineering of this strain for the production of value-added chemicals from methane

ISSN 

2073-4344

Link 

http://dx.doi.org/10.3390/catal8030117

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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