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Title 

In vitro and in vivo safety studies of cinnamon extract (Cinnamomum cassia) on general and genetic toxicology

Authors 

J W YunJ R YouY S KimS H KimE Y ChoJ H YoonE KwonJ J JangJ S ParkHyoung-Chin KimJ H CheB C Kang

Publisher 

Elsevier

Issue Date 

2018

Citation 

Regulatory Toxicology and Pharmacology

Keywords 

Cinnamomum cassiaCinnamonGenotoxicitySubchronicToxicity

Abstract 

Cinnamomum cassia has been widely used as a natural product to treat diseases in Asia due to its diverse pharmacological functions including anti-inflammatory, anti-oxidant, anti-microbial, anti-diabetic, and anti-tumor effects. Despite its ethnomedicinal benefits, little information regarding its toxicity is currently available. The aim of this study was to evaluate its potential long-term toxicity and genotoxicity in compliance with test guidelines of the Organization for Economic Cooperation and Development. A 13-week repeat-dose oral toxicity study revealed that body weights of rats were normal after receiving cinnamon extract at up to 2000 mg/kg. High-dose intake of cinnamon extract (2000 mg/kg) showed potential nephrotoxicity and hepatotoxicity to both males and females as evidenced by obvious increases of kidney/liver weight along with a small but statistically elevation of total cholesterol level. Overall findings from genetic toxicity testing battery including Ames test, in vitro mammalian cell micronucleus assay, and in vivo bone marrow micronucleus assay indicated that cinnamon extract was not mutagenic or clastogenic. In conclusion, cinnamon extract may possess potential nephrotoxicity and hepatotoxicity at dose higher than its recommended daily safe dose. Further study is needed to clarify the mechanism involved in its induction of liver and kidney injury

ISSN 

0273-2300

Link 

http://dx.doi.org/10.1016/j.yrtph.2018.02.017

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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