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Title 

Gemcitabine and nucleos(t)ide synthesis inhibitors are broad-spectrum antiviral drugs that activate innate immunity

 

Gemcitabine, nucleoside analogs의 innate immunity를 통한 항바이러스 효능

Authors 

H J ShinC KimSungchan Cho

Publisher 

MDPI

Issue Date 

2018

Citation 

Viruses

Keywords 

Antiviral drugsGemcitabineInnate immunityInterferon-stimulated geneNucleos(t)ide synthesisNucleoside analog

Abstract 

Nucleoside analogs have been frequently identified as antiviral agents. In recent years, gemcitabine, a cytidine analog in clinical use for the treatment of many solid tumors, was also shown to have antiviral activity against a broad range of viruses. Nucleoside analogs generally interfere with cellular nucleos(t)ide synthesis pathways, resulting in the depletion or imbalance of (d)NTP pools. Intriguingly, a few recent reports have shown that some nucleoside analogs, including gemcitabine, activated innate immunity, inducing the expression of interferon-stimulated genes, through nucleos(t)ide synthesis inhibition. The precise crosstalk between these two independent processes remains to be determined. Nonetheless, we summarize the current knowledge of nucleos(t)ide synthesis inhibition-related innate immunity and propose it as a newly emerging antiviral mechanism of nucleoside analogs

ISSN 

1999-4915

Link 

http://dx.doi.org/10.3390/v10040211

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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