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Title 

Metabolic engineering of Corynebacterium glutamicum for fermentative production of chemicals in biorefinery

Authors 

K A BaritugoH T KimY DavidJ I ChoiS H HongK J JeongJong Hyun ChoiJ C JooS J Park

Publisher 

Springer Verlag (Germany)

Issue Date 

2018

Citation 

Applied Microbiology and Biotechnology

Keywords 

Bio-based chemicalsCorynebacterium glutamicumMetabolic engineeringMicrobial cell factoryPlasmid vectorsPromoters

Abstract 

Bio-based production of industrially important chemicals provides an eco-friendly alternative to current petrochemical-based processes. Because of the limited supply of fossil fuel reserves, various technologies utilizing microbial host strains for the sustainable production of platform chemicals from renewable biomass have been developed. Corynebacterium glutamicum is a non-pathogenic industrial microbial species traditionally used for l-glutamate and l-lysine production. It is a promising species for industrial production of bio-based chemicals because of its flexible metabolism that allows the utilization of a broad spectrum of carbon sources and the production of various amino acids. Classical breeding, systems, synthetic biology, and metabolic engineering approaches have been used to improve its applications, ranging from traditional amino-acid production to modern biorefinery systems for production of value-added platform chemicals. This review describes recent advances in the development of genetic engineering tools and techniques for the establishment and optimization of metabolic pathways for bio-based production of major C2?C6 platform chemicals using recombinant C. glutamicum

ISSN 

0175-7598

Link 

http://dx.doi.org/10.1007/s00253-018-8896-6

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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