상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype

Authors 

S C OhB H SohnJ H CheongS B KimJ E LeeK C ParkS H LeeJong Lyul ParkY Y ParkH S LeeH J JangE S ParkS C KimJ HeoIn-Sun ChuY J JangY J MokW JungB H KimA KimS H NohG B MillsSeon-Young KimJ A AjaniJ S Lee

Publisher 

Nature Publishing Group

Issue Date 

2018

Citation 

Nature Communications

Abstract 

Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial phenotype (EP), by analyzing genomic and proteomic data. Molecularly, MP subtype tumors show high genomic integrity characterized by low mutation rates and microsatellite stability, whereas EP subtype tumors show low genomic integrity. Clinically, the MP subtype is associated with markedly poor survival and resistance to standard chemotherapy, whereas the EP subtype is associated with better survival rates and sensitivity to chemotherapy. Integrative analysis shows that signaling pathways driving epithelial-to-mesenchymal transition and insulin-like growth factor 1 (IGF1)/IGF1 receptor (IGF1R) pathway are highly activated in MP subtype tumors. Importantly, MP subtype cancer cells are more sensitive to inhibition of IGF1/IGF1R pathway than EP subtype. Detailed characterization of these two subtypes could identify novel therapeutic targets and useful biomarkers for prognosis and therapy response

ISSN 

2041-1723

Link 

http://dx.doi.org/10.1038/s41467-018-04179-8

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)