상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Early postnatal valproic acid exposure increase the protein level of astrocyte markers in frontal cortex of rat

Authors 

T J MonyJae Won LeeS S KimW ChunH J Lee

Publisher 

Korean College of Neuropsychopharmacology

Issue Date 

2018

Citation 

Clinical Psychopharmacology and Neuroscience

Keywords 

Frontal cortexImmunoblottingNeurogliaPostnatal developmentValproic acid

Abstract 

Objective: In our previous study, it has been reported that valproic acid (VPA) effects gliogenesis and increases the number of glial precursor cells during the early postnatal period. However there is no specific report that whether this process is going on up to the age of mature brain development and the consequence effect of this ongoing gliogenesis process. Methods: As an ongoing study, using Immunoblotting analysis, we checked the level of glial protein and glial-derived factor markers in the frontal cortex of a rat brain at postnatal day (PND) 21. Results: The finding of the study suggests that, in the VPA group (p<0.05), early exposure elicited significantly to increase the expression level of glial protein cells at PND 21 in the frontal cortex of rat brain. Conclusion: Therefore we suggest that, alter gliogenesis and abnormal number of glial cells modulate the neurobiological dysfunction and induces the risk of neurodevelopmental disorders.

ISSN 

1738-1088

Link 

http://dx.doi.org/10.9758/cpn.2018.16.2.214

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)