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Title 

Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer

Authors 

M H KangH ChoiM OshimaJ H CheongSeok Ho KimJ H LeeY S ParkH S ChoiM N KweonC G PackJ S LeeG B MillsS J MyungY Y Park

Publisher 

Nature Publishing Group

Issue Date 

2018

Citation 

Nature Communications

Abstract 

The principle factors underlying gastric cancer (GC) development and outcomes are not well characterized resulting in a paucity of validated therapeutic targets. To identify potential molecular targets, we analyze gene expression data from GC patients and identify the nuclear receptor ESRRG as a candidate tumor suppressor. ESRRG expression is decreased in GC and is a predictor of a poor clinical outcome. Importantly, ESRRG suppresses GC cell growth and tumorigenesis. Gene expression profiling suggests that ESRRG antagonizes Wnt signaling via the suppression of TCF4/LEF1 binding to the CCND1 promoter. Indeed, ESRRG levels are found to be inversely correlated with Wnt signaling-associated genes in GC patients. Strikingly, the ESRRG agonist DY131 suppresses cancer growth and represses the expression of Wnt signaling genes. Our present findings thus demonstrate that ESRRG functions as a negative regulator of the Wnt signaling pathway in GC and is a potential therapeutic target for this cancer

ISSN 

2041-1723

Link 

http://dx.doi.org/10.1038/s41467-018-04244-2

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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