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Title 

Four new compounds isolated from Psoralea corylifolia and their diacylglycerol acyltransferase (DGAT) inhibitory activity

Authors 

X LinB B LiL ZhangH Z LiX MengY Y JiangHyun Sun LeeL Cui

Publisher 

Elsevier

Issue Date 

2018

Citation 

Fitoterapia

Keywords 

Bu-Gu-ZhiDGATLeguminosaeP. corylifolia

Abstract 

A new bakuchiol compound Δ11-12-hydroxy-12-dimethyl bakuchiol (1), a new flavanone compound 2(S)-6-methoxy-7- hydroxymethylene-4′-hydroxyl-flavanone (8), and two new isoflavanone compounds 4′,7-dihydroxy-3′-(6”β-hydroxy-3″,7″-dimethyl-,2″,7″-dibutenyl)-geranylisoflavone (9) and 4′,7-dihydroxy-3′-(7″-hydroxy-7″-methyl-2″,5″-dibutenyl)-geranylisoflavone (10) together with eight known compounds (2?7, 11, 12) were isolated from the P. corylifolia. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1/2. Among them, compounds 3, 9 and 10 were found to exhibit selective inhibitory activity on DGAT1 with IC50 values ranging from 93.7 ± 1.3 to 96.2 ± 1.1 μM. Compound 1 showed inhibition activity on DGAT1 with IC50 values 73.4 ± 1.3 μM and inhibition of DGAT2 with IC50 value 121.1 ± 1.3 μM

ISSN 

0367-326X

Link 

http://dx.doi.org/10.1016/j.fitote.2018.05.004

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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