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Title 

Cytotoxic drimane sesquiterpenoids isolated from Perenniporia maackiae

Authors 

J KwonH LeeY H SeoJ YunJ LeeH C KwonY GuoJong Soon KangJ J KimD Lee

Publisher 

American Chemical Society

Issue Date 

2018

Citation 

Journal of Natural Products

Abstract 

A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 μM.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/acs.jnatprod.8b00175

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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