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Title 

Estrogenic effects of phytoestrogens derived from Flemingia strobilifera in MCF-7 cells and immature rats

Authors 

S Y JeongM ChangSang-ho ChoiSei-Ryang OhH W WuY ZhuX M GaoX WangB ZhangD S LimJ Y LeeS D KimY S Song

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2018

Citation 

Archives of Pharmacal Research

Keywords 

ERE transcriptionEstrogen receptorFlemingia strobiliferaImmature ratPhytoestrogenUterotrophic effect

Abstract 

Phytoestrogen (PE) has received considerable attention due to the physiological significance of its estrogenicity. Flemingia strobilifera (FS) has been used as a folk medicine in Asia for the treatment of inflammation, cancer, and infection; however, the estrogenic effects and chemical components of FS have not yet been reported. We aimed to uncover the estrogenic properties and PEs derived from FS using phytochemical and pharmacological evaluation. PEs from FS extract (FSE) were analyzed by NMR, HPLC, and MS. To evaluate estrogenic activity, FSE and its compounds were evaluated by in vitro and in vivo assays, including human estrogen receptor alpha (hERα) binding, estrogen response element (ERE)-luciferase reporter assays, and uterotrophic assays. FSE and its compounds 1?5 showed binding affinities for hERα and activated ERE transcription in MCF-7 cells. Additionally, FSE and compounds 1?5 induced MCF-7 cell proliferation and trefoil factor 1 (pS2) expression. In immature female rats, significant increases in uterine weight and pS2 gene were observed in FSE-treated groups. We identified estrogenic activities of FSE and its bioactive compounds, suggesting their possible roles as PEs via ERs. PEs derived from FSE are promising candidates for ER-targeted therapy for post-menopausal symptoms

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-018-1027-1

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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