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Title 

Isolation, synthesis, and antisepsis effects of a C-methylcoumarinochromone isolated from Abronia nana cell culture

Authors 

Wonhwa LeeD LeeY LeeT LeeK S SongE J YangJ S Bae

Publisher 

American Chemical Society

Issue Date 

2018

Citation 

Journal of Natural Products

Abstract 

Only a few isoflavones have been isolated from plants of the genus Abronia. The biological properties of compounds isolated from Abronia species have not been well established, and their antisepsis effects have not been reported yet. In the present study, a new C-methylcoumarinochromone, was isolated from Abronia nana suspension cultures. Its structure was deduced as 9,11-dihydroxy-10-methylcoumarinochromone (boeravinone Y, 1) by spectroscopic data analysis and verified by chemical synthesis. The potential inhibitory effects of 1 against high mobility group box 1 (HMGB1)-mediated septic responses were investigated. Results showed that 1 effectively inhibited lipopolysaccharide-induced release of HMGB1 and suppressed HMGB1-mediated septic responses, in terms of reduction of hyperpermeability, leukocyte adhesion and migration, and cell adhesion molecule expression. In addition, 1 increased the phagocytic activity of macrophages and exhibited bacterial clearance effects in the peritoneal fluid and blood of mice with cecal ligation and puncture-induced sepsis. Collectively, these results suggested that 1 might have potential therapeutic activity against various severe vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/acs.jnatprod.7b00826

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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