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Title 

Comparative in silico profiling of epigenetic modifiers in human tissues

Authors 

Mi Young SonCho Rok JungDae Soo KimHyun Soo Cho

Publisher 

Springer Verlag (Germany)

Issue Date 

2018

Citation 

Molecular Biology Reports

Keywords 

Human tissueIn silico epigenetic panelRNA-seq

Abstract 

The technology of tissue differentiation from human pluripotent stem cells has attracted attention as a useful resource for regenerative medicine, disease modeling and drug development. Recent studies have suggested various key factors and specific culture methods to improve the successful tissue differentiation and efficient generation of human induced pluripotent stem cells. Among these methods, epigenetic regulation and epigenetic signatures are regarded as an important hurdle to overcome during reprogramming and differentiation. Thus, in this study, we developed an in silico epigenetic panel and performed a comparative analysis of epigenetic modifiers in the RNA-seq results of 32 human tissues. We demonstrated that an in silico epigenetic panel can identify epigenetic modifiers in order to overcome epigenetic barriers to tissue-specific differentiation

ISSN 

0301-4851

Link 

http://dx.doi.org/10.1007/s11033-018-4163-2

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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