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Title 

Peroxiredoxin I deficiency increases LPS induced lethal shock in mice

Authors 

H N SunL FengA G WangJ Y WangL LiuM H JinG N ShenC H JinD S LeeT H KwonY D CuiDae Yeul YuY H Han

Publisher 

Spandidos Publications

Issue Date 

2018

Citation 

Molecular Medicine Reports

Keywords 

ApoptosisCytokineLethal shockLipopolysaccharidePeroxiredoxin I

Abstract 

Peroxiredoxin I (Prx I) plays a role in regulating macrophage proinflammatory cytokine production and gene expression and participates in immune regulation. However, the possible protective role of Prx I in endotoxin-induced lethal shock is poorly understood. In the present study, western blot analysis, ELISA and haematoxylin and eosin staining were performed to examine the protein expression of cytoines and analyses the levels of cytokines in the serum and tissue to evaluate the tissue damage. The present study revealed that lipopolysaccharide (LPS)-induced lethality in Prx I-/- mice was is accelerated via the observed decreased serum IL-10 levels. Results also demonstrated rapid immune cell infiltration and oxidative stress in the Prx I-/-mice liver after LPS injections. These phenomena increased liver apoptosis through increasing cleaved caspase-3 protein expression in Prx I-/- mice after LPS injections, resulting in high lethality after LPS challenges. These findings provide a new insight for understanding the function of Prx I against endotoxin-induced injury

ISSN 

1791-2997

Link 

http://dx.doi.org/10.3892/mmr.2018.9170

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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