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Title 

Anti-inflammatory phomalichenones from an endolichenic fungus Phoma sp.

 

지의류 내생 곰팡이로부터 분리한 항염증 물질

Authors 

Jong Won KimW KoE KimGil Soo KimGui-Ja HwangSangkeun SonM H JeongJ S HurH OhSung-Kyun KoJae-Hyuk JangJong Seog Ahn

Publisher 

Nature Publishing Group

Issue Date 

2018

Citation 

Journal of Antibiotics

Abstract 

Four new compounds, phomalichenones A-D (1-4), and seven known compounds (5-11) were isolated from the cultures of an endolichenic fungus Phoma sp. EL002650. Their structures were determined by the analysis of their spectroscopic data (NMR and MS). Compounds 1 and 6 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. In addition, compound 1 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin(IL)-1β, and IL-6.

ISSN 

0021-8820

Link 

http://dx.doi.org/10.1038/s41429-018-0058-7

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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