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Title 

Molybdate attenuates lipid accumulation in the livers of mice fed a diet deficient in methionine and choline

Authors 

S LeeKi Hoan NamJ K SeongD Y Ryu

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2018

Citation 

Biological & Pharmaceutical Bulletin

Keywords 

autophagyfatty liverhepatotoxicitymolybdenumoxidative stress

Abstract 

Both lipid accumulation and oxidative stress are major pathologic contributors to the development of hepatic steatosis. Treatment with molybdate reduces hepatic levels of lipids in diabetic rats. Potential activities of molybdate as an antioxidant have also been demonstrated in various animal models. In the present study, we evaluated the effects of sodium molybdate dihydrate (SM) on hepatic steatosis and associated disturbances in a widely used mouse model of the metabolic disease. Male C57Bl/6 mice at 10 weeks of age were fed a diet deficient in methionine and choline (MCD) and bottled water containing SM for four weeks. The SM treatment markedly attenuated MCD-induced accumulation of lipids, mainly triglycerides, in the liver. Lipid catabolic autophagic pathways were activated by SM in the MCD-fed mouse livers, as evidenced by a decreased level of p62 expression. MCD-induced oxidative damage, such as lipid and protein oxidation, was also alleviated by SM in the liver. However, the level of MCD-induced hepatocellular damage was not affected by SM. Taken together, these findings suggest that molybdate can be used in the treatment and prevention of hepatic steatosis without inducing adverse effects in the liver. To the best of our knowledge, this is the first experimental study to investigate the effects of molybdate in non-alcoholic fatty liver disease, and also the first that demonstrates molybdate-induced autophagy.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.b18-00020

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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