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Title 

Wogonin suppresses the LPS?enhanced invasiveness of MDA?MB?231 breast cancer cells by inhibiting the 5?LO/BLT2 cascade

 

오고닌의 5-LO/BLT2 경로를 통한 MDA-MB-231 유방암세포의 침윤 억제 활성

Authors 

J H GoJ D WeiJ I ParkKyung Seop AhnJae-Hong Kim

Publisher 

Spandidos Publications

Issue Date 

2018

Citation 

International Journal of Molecular Medicine

Keywords 

5-lipoxygenaseBreast cancerInteleukin-8InvasivenessLeuko- triene B4 receptor 2LipopolysaccharideMatrix metallopeptidase-9MDA-MB-231 cellsMetastasisWogonin

Abstract 

Wogonin, a naturally occurring bioactive monoflavonoid isolated from Scutellariae radix (roots of Scutellariae baicalensis Georgi), has known anticancer effects. However, the molecular signaling mechanism by which wogonin inhibits invasiveness in breast cancer cells remains unclear. In the present study, it was observed that wogonin exerted an inhibitory effect on the lipopolysaccharide (LPS)?enhanced invasiveness of MDA?MB?231 cells. In addition, wogonin inhibited the synthesis of interleukin?8 (IL?8) and matrix metallopeptidase?9 (MMP?9), which are critical for promoting invasiveness in MDA?MB?231 cells. Wogonin also suppressed the expression of leukotriene B4 receptor 2 (BLT2) and the synthesis of its ligand, by inhibiting 5?lipoxygenase (5?LO) in LPS?stimulated MDA?MB?231 cells. Notably, wogonin attenuated the production of IL?8 and MMP?9 by inhibiting the BLT2/extracellular signal?regulated kinase (ERK)?linked cascade. Finally, in vivo, LPS?driven MDA?MB?231 cell metastasis was markedly suppressed by wogonin administration. Overall, the present results suggested that wogonin inhibited the 5?LO/BLT2/ERK/IL?8/MMP?9 signaling cascade and demonstrated that this cascade may be an important target through which wogonin exerts its anticancer effects in breast cancer.

ISSN 

1107-3756

Link 

http://dx.doi.org/10.3892/ijmm.2018.3776

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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