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Title 

IDH2-deficient mice develop spinal deformities with aging

Authors 

U ChaeN R ParkE S KimJ Y ChoiM YimH S LeeSang-Rae LeeS LeeJ W ParkD S Lee

Publisher 

Elsevier

Issue Date 

2018

Citation 

Physiological Research

Keywords 

AgingAnimal modelsIsocitrate dehydrogenase 2OsteoblastOsteoclastSpinal deformity

Abstract 

Spinal deformities such as scoliosis and kyphosis are incurable, and can lead to decreased physical function, pain, and reduced quality of life. Despite much effort, no clear therapies for the treatment of these conditions have been found. Therefore, the development of an animal model for spinal deformity would be extremely valuable to our understanding of vertebral diseases. In this study, we demonstrate that mice deficient in the mitochondrial enzyme isocitrate dehydrogenase 2 (IDH2) develop spinal deformities with aging. We use morphological analysis as well as radiographic and micro-CT imaging of IDH2-deficient mice to characterize these deformities. Histological analysis showed increased abnormalities in IDH2-deficient mice compared to wild type mice. Taken together, the results suggest that IDH2 plays a critical role in maintaining the spinal structure by affecting the homeostatic balance between osteoclasts and osteoblasts. This indicates that IDH2 might be a potent target for the development of therapies for spinal deformities. Our findings also provide a novel animal model for vertebral disease research. ? 2018 Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.

ISSN 

0862-8408

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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