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Title 

A novel voxel-wise lesion segmentation technique on 3.0-T diffusion MRI of hyperacute focal cerebral ischemia at 1?h after permanent MCAO in rats

Authors 

C H ChoiK S YiSang-Rae LeeYoungjeon LeeChang Yeop JeonJ HwnagC LeeS S ChoiH J LeeS H Cha

Publisher 

SAGE Publications

Issue Date 

2018

Citation 

Journal of Cerebral Blood Flow and Metabolism

Keywords 

Brain ischemiaacute strokeanimal modelsbrain imagingdiffusion-weighted MRI

Abstract 

To assess hyperacute focal cerebral ischemia in rats on 3.0-Tesla diffusion-weighted imaging (DWI), we developed a novel voxel-wise lesion segmentation technique that overcomes intra- and inter-subject variation in apparent diffusion coefficient (ADC) distribution. Our novel technique involves the following: (1) intensity normalization including determination of the optimal type of region of interest (ROI) and its intra- and inter-subject validation, (2) verification of focal cerebral ischemic lesions at 1?h with gross and high-magnification light microscopy of hematoxylin-eosin (H&E) pathology, (3) voxel-wise segmentation on ADC with various thresholds, and (4) calculation of dice indices (DIs) to compare focal cerebral ischemic lesions at 1?h defined by ADC and matching H&E pathology. The best coefficient of variation was the mode of the left hemisphere after normalization using whole left hemispheric ROI, which showed lower intra- (2.54?±?0.72%) and inter-subject (2.67?±?0.70%) values than the original. Focal ischemic lesion at 1?h after middle cerebral artery occlusion (MCAO) was confirmed on both gross and microscopic H&E pathology. The 83 relative threshold of normalized ADC showed the highest mean DI (DI?=?0.820?±?0.075). We could evaluate hyperacute ischemic lesions at 1?h more reliably on 3-Tesla DWI in rat brains.

ISSN 

0271-678X

Link 

http://dx.doi.org/10.1177/0271678X17714179

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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