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Title 

Synthetic efforts towards the stereoselective synthesis of NF00659B1

Authors 

D Y KwonK LeeH ParkMi Jung KimJ Hong

Publisher 

Elsevier

Issue Date 

2018

Citation 

Bioorganic & Medicinal Chemistry Letters

Keywords 

Colon cancerDimethyl oxepanolNF00659B(1)Natural productsOlefinic ester ring-closing metathesisPyrone diterpenoid

Abstract 

NF00659B1 is a novel α-pyrone diterpenoid natural product with potent anti-colon cancer activity. A stereoselective approach to the 2,2-dimethyl oxepanol core of NF00659B1 is described enlisting a sequence of olefinic ester ring-closing metathesis, epoxidation, and Grignard addition. This strategy paves the way to a total synthesis of NF00659B1 for further biological studies.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2018.02.038

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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