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Title 

Cardioprotective effect of substance P in a porcine model of acute myocardial infarction

Authors 

D S SimW KimK H LeeH C SongJ H KimD S ParkKyung Seob LimJ S WooY J HongY AhnH S HongY SonM H Jeong

Publisher 

Elsevier

Issue Date 

2018

Citation 

International Journal of Cardiology

Keywords 

Myocardial infarctionReperfusionVentricular remodeling

Abstract 

Background: Substance P (SP) may attenuate ischemia-reperfusion injury by reducing inflammation. We assessed cardioprotective effect of SP in a porcine model of acute myocardial infarction (AMI). Methods: AMI was induced by occlusion of the left anterior descending artery on 28 swine, randomized to SP 5 nmol/kg (group 1, n = 14) and normal saline (group 2, n = 14) given intravenously 5 min before reperfusion. Blood samples were collected at baseline, 3 days and 4 weeks. Echocardiography and myocardial perfusion single photon emission computed tomography (SPECT) were performed at 1 week and 4 weeks. Histomorphometric infarct size assessment was done at 4 weeks. Results: Left ventricular (LV) ejection fraction (EF) (LVEF) after AMI induction was higher in group 1 than group 2 (37.9 ± 4.6% vs. 29.4 ± 3.2%, p = 0.001) but not different at 4 weeks. No significant difference was observed in perfusion defect extent and total perfusion defect on SPECT at 1 week and 4 weeks. Pathologic infarct size (% LV) was significantly smaller in group 1 than group 2 (2.4 ± 2.3% vs. 5.7 ± 2.5%, p = 0.020). The ratio of neutrophil to lymphocyte on day 3 and serum creatinine concentration at 4 weeks after AMI were lower in group 1. Conclusions: In a porcine model of AMI, SP improved LVEF early post-MI and reduced infarct size. SP may be beneficial in reducing inflammation and ischemia-reperfusion injury after AMI.

ISSN 

0167-5273

Link 

http://dx.doi.org/10.1016/j.ijcard.2018.05.113

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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