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Title 

Enhanced neutralizing antibody response induced by inactivated enterovirus 71 in cynomolgus monkeys

Authors 

H J InH LimJ A LeeSang-Rae LeeYeung Bae JinKang Jin JeongJ Y HyeonJ S YooJ W LeeY K ChoiS W Lee

Publisher 

Public Library of Science

Issue Date 

2018

Citation 

Plos One

Abstract 

Enterovirus 71 (EV71) is a major etiological agent of various public health issues, particularly in the Asia-Pacific region. EV71 causes hand-foot-and-mouth disease (HFMD) and is associated with serious neurological disorders in young children. A formalin-inactivated EV71 candidate vaccine (KCDC-HFMDV1-EV71) based on the C4 subgenotype was previously developed and confirmed to be a potential candidate vaccine for prevention of EV71 infection in mice. In this study, an inactivated EV71 vaccine was used for analysis of long-term immunogenicity and efficacy in cynomolgus monkeys, a common nonhuman primate model. The vaccine was immunized three times at 0, 4, and 8 weeks with either 20-μg doses of EV71 candidate vaccine formulated with aluminum hydroxide gel adjuvant or phosphate-buffered saline as a control. The group immunized with the inactivated EV71 showed significantly increased EV71-specific antibody and serum neutralizing antibody titers at 3 weeks after vaccination and maintained these elevated titers until the end of the experiment (54 weeks after vaccination). The sera from vaccinated cynomolgus monkeys showed a crossreactive neutralizing antibody response to the heterologous subtype of EV71 (B1-4, C1, and C2). These findings suggest that the inactivated EV71 candidate vaccine may be a potential vaccine candidate and valuable tool for the control of HFMD.

ISSN 

1932-6203

Link 

http://dx.doi.org/10.1371/journal.pone.0202552

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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