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Title 

Generation of whole-genome sequencing data for comparing primary and castration-resistant prostate cancer

Authors 

Jong Lyul ParkSeon-Kyu KimJeong Hwan KimS J YunW J KimW T KimP JeongH W KangSeon-Young Kim

Publisher 

Korea Genome Organization

Issue Date 

2018

Citation 

Genomics & Informatics

Keywords 

DNA variantscastration-resistant prostate cancerwhole-genome sequencing

Abstract 

Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CRPC tissues compared with primary PC tissues (range, 1,691 to 21,705). Our whole-genome sequencing data of primary PC and CRPC may be useful for understanding the genomic changes and molecular mechanisms that occur during the progression from PC to CRPC.

ISSN 

1598-866X

Link 

http://dx.doi.org/10.5808/GI.2018.16.3.71

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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