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Title 

PreSMo target-binding signatures in intrinsically disordered proteins

Authors 

Do-hyoung KimKyou Hoon Han

Publisher 

Springer Verlag (Germany)

Issue Date 

2018

Citation 

Molecules and Cells

Keywords 

IDPsIDR (Intrinsically Disordered Region)IUPs (Intrinsically Unfolded Proteins)NMRPreSMos (Pre-Structured Motifs)

Abstract 

Intrinsically disordered proteins (IDPs) are highly unorthodox proteins that do not form three-dimensional structures under physiological conditions. The discovery of IDPs has destroyed the classical structure-function paradigm in protein science, 3-D structure = function, because IDPs even without well-folded 3-D structures are still capable of performing important biological functions and furthermore are associated with fatal diseases such as cancers, neurodegenerative diseases and viral pandemics. Pre-structured motifs (PreSMos) refer to transient local secondary structural elements present in the target-unbound state of IDPs. During the last two decades PreSMos have been steadily acknowledged as the critical determinants for target binding in dozens of IDPs. To date, the PreSMo concept provides the most convincing structural rationale explaining the IDP-target binding behavior at an atomic resolution. Here we present a brief developmental history of PreSMos and describe their common characteristics. We also provide a list of newly discovered PreSMos along with their functional relevance.

ISSN 

1016-8478

Link 

http://dx.doi.org/10.14348/molcells.2018.0192

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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