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Title 

Nothofagin suppresses mast cell-mediated allergic inflammation

 

Nothofagin의 비만세포 연계 알러지염증 저해 효과

Authors 

B C KangM J KimSoyoung LeeY A ChoiP H ParkT Y ShinT K KwonD KhangS H Kim

Publisher 

Elsevier

Issue Date 

2019

Citation 

Chemico-Biological Interactions

Keywords 

Allergic inflammationHistamineMast cellsNothofagin

Abstract 

Mast cells play a major role in immunoglobulin E-mediated allergic inflammation, which is involved in asthma, atopic dermatitis, and allergic rhinitis. Nothofagin has been shown to ameliorate various inflammatory responses such as the septic response and vascular inflammation. In this study, we assessed the inhibitory effect of nothofagin on allergic inflammation using cultured/isolated mast cells and an anaphylaxis mouse model. Nothofagin treatment prevented histamine and β-hexosaminidase release by reducing the influx of calcium into the cytosol in a concentration-dependent manner. Nothofagin also inhibited the gene expression and secretion of pro-inflammatory cytokines such as tumor necrosis factor-α and interleukin-4 by downregulating the phosphorylation of Lyn, Syk, Akt and nuclear translocation of nuclear factor-κB. To confirm these effects of nothofagin in vivo, we used a passive cutaneous anaphylaxis mouse model. Topical administration of nothofagin suppressed local pigmentation and ear thickness. Taken together, these results suggest nothofagin as a potential candidate for the treatment of mast cell-involved allergic inflammatory diseases.

ISSN 

0009-2797

Link 

http://dx.doi.org/10.1016/j.cbi.2018.10.025

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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