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Title 

Sicyos angulatus ameliorates acute liver injury by inhibiting oxidative stress via upregulation of anti-oxidant enzymes

Authors 

Hyun-Yong KimJung-Ran NohSung-Je MoonDong Hee ChoiYong-Hoon KimKyoung Shim KimH S YookJ P AnW K OhJung Hwan HwangChul Ho Lee

Publisher 

Taylor & Francis Open

Issue Date 

2018

Citation 

Redox Report

Keywords 

Antioxidantsapoptosisenzymeextractsinjuryliveroxidative stressreactive oxygen species

Abstract 

OBJECTIVE: We aimed to investigate the effect of Sicyos angulatus (SA) ethanolic extracts as antioxidants and potential treatments for liver disease. METHODS: To establish a mouse model of liver injury, C57BL/6 male mice were injected via the caudal vein with a single dose of concanavalin A (Con A, 15?mg?kg-1). SA extracts were administered once by oral gavage 30?min before Con A injection. RESULTS: In vitro studies showed that SA decreased tert-butyl hydroperoxide (t-BHP)-induced reactive oxygen species (ROS) production. SA administration reduced plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, as well as hepatic ROS levels, in a dose-dependent manner. Moreover, SA increased the activities of the hepatic antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase in a dose-dependent manner. Furthermore, SA treatment reduced pro-apoptotic protein levels. Con A-mediated cytosolic release of Smac/DIABLO and apoptosis-inducing factor (AIF), which are markers of necrosis, were dramatically decreased in HepG2 cells treated with SA. CONCLUSION: SA ameliorated liver injury and might be a good strategy for the treatment of liver injury.

ISSN 

1351-0002

Link 

http://dx.doi.org/10.1080/13510002.2018.1546986

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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