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Title 

Effects of the extracts from fruit and stem of Camellia japonica on induced pluripotency and wound healing

 

전분화능 및 운드힐링에서의 식물추출물 효과

Authors 

Hyejin JeonJae Yun KimJung Kyun ChoiEnna HanCho Lok SongJungwoon LeeYee Sook Cho

Publisher 

MDPI

Issue Date 

2018

Citation 

Journal of Clinical Medicine

Keywords 

induced pluripotent stem cellplant extractsreprogrammingwound healing

Abstract 

Small molecules that improve reprogramming, stem cell properties, and regeneration can be widely applied in regenerative medicine. Natural plant extracts represent an abundant and valuable source of bioactive small molecules for drug discovery. Natural products themselves or direct derivatives of them have continued to provide small molecules that have entered clinical trials, such as anticancer and antimicrobial drugs. Here, we tested 3695 extracts from native plants to examine whether they can improve induced pluripotent stem cell (iPSC) generation using genetically homogeneous secondary mouse embryonic fibroblasts (MEFs) harboring doxycycline (dox)-inducible reprograming transgenes. Among the tested extracts, extracts from the fruit and stem of Camellia japonica (CJ) enhanced mouse and human iPSC generation and promoted efficient wound healing in an in vivo mouse wound model. CJ is one of the best-known species of the genus Camellia that belongs to the Theaceae family. Our findings identified the natural plant extracts from the fruit and stem of CJ as novel regulators capable of enhancing cellular reprogramming and wound healing, providing a useful supplement in the development of a more efficient and safer method to produce clinical-grade iPSCs and therapeutics.

ISSN 

2077-0383

Link 

http://dx.doi.org/10.3390/jcm7110449

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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